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CAS No.: 34080-08-5

(S型)原人参三醇 Catalog No. CSN23624

Synonyms: 20(S)-APPT;g-PPT;20(S)-Protopanaxatriol

(20S)-Protopanaxatriol, a metabolite of ginsenoside, can modulate endothelial cell functions via the glucocorticoid receptor (GR) and oestrogen receptor (ER).

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生物活性

描述(20S)-Protopanaxatriol is a metabolite of ginsenoside, works through the glucocorticoid receptor (GR) and oestrogen receptor (ER) in human umbilical vein endothelial cells (HUVECs), and is also a LXRα inhibitor. (20S)-Protopanaxatriol (g-PPT) increases [Ca2+]i with an EC50 of 482 nM in HUVECs^[2]. PPT((20S)-Protopanaxatriol) inhibited the LXRα-dependent transcription of lipogenic genes, such as sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase, and stearoyl CoA desaturase 1. Furthermore, LXRα-dependent triglyceride accumulation in primary mouse hepatocytes was significantly reduced by PPT^[3]. PPT enhanced adipogenesis by increasing the expression of PPARgamma target genes such as aP2, LPL and PEPCK. Furthermore, PPT significantly increased expression of glucose transporter 4 (GLUT4). PPT can be developed as a PPARgamma (Peroxisome proliferator-activated receptor gamma) agonist for the improvement of insulin resistance associated with diabetes^[4].
参考文献

[2] Leung KW, Leung FP, Mak NK, Tombran-Tink J, Huang Y, Wong RN. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells. Br J Pharmacol. 2009 Feb;156(4):626-37
[3] Oh GS, Yoon J, Lee GG, Oh WK, Kim SW. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes. J Pharmacol Sci. 2015 Jun;128(2):71-7
[4] Han KL, Jung MH, Sohn JH, Hwang JK. Ginsenoside 20S-protopanaxatriol (PPT) activates peroxisome proliferator-activated receptor gamma (PPARgamma) in 3T3-L1 adipocytes. Biol Pharm Bull. 2006 Jan;29(1):110-3

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0976 mL
- 10.4881 mL
- 20.9762 mL
- 5 mM
- 0.4195 mL
- 2.0976 mL
- 4.1952 mL
- 10 mM
- 0.2098 mL
- 1.0488 mL
- 2.0976 mL

技术信息

CAS号

34080-08-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H52O4

运输

蓝冰

分子量

476.73

别名

20(S)-APPT;g-PPT;20(S)-Protopanaxatriol;20(S)-PPT;20 (S)-原人参三醇;原人参三醇

溶解度

DMSO	95.0 mg/mL (199.3 mM)
Water	Insoluble
Ethanol	94.0 mg/mL (197.2 mM)

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